Axel Ullrich

Wolf Prize Laureate in Medicine 2010

The Prize Committee for Physics has unanimously decided that the 2010 Wolf Prize be awarded to:

 

Axel Ullrich

Max Planck Institute of Biochemistry
Munich, Germany

 

“For his pioneering contributions to the discovery and characterization of human proto-onco-genes and the development of novel cancer therapies.”

 

Professor Axel Ullrich (born1943, Germany) and colleagues reported the cloning of the cDNA encoding the epidermal growth factor receptor (EGFR), in 1984. This opened up the field of Signal Transduction research. Subsequently, Ullrich confirmed the existence of animal oncogene-related human proto-oncogenes, by cloning the human homologs of v-fms and v-kit; and thereby establishing “cancer targets” for therapy development, at a very early stage.

 

In 1985, the discovery by Ullrich and his collaborators, of an EGFR-related gene, HER2/c-erbB2, led to Herceptin, the first cancer therapeutic based on genome research. Ullrich initiated collaboration with Dennis Slamon, towards the genomic analysis of primary breast tumors, which led to the discovery that the gene encoding HER2 is amplified and over-expressed in 25 percent of all breast cancers; and that HER2 amplification predicts rapid disease progression. Ullrich’s laboratory then developed monoclonal antibodies for HER2, one of which, MAb 4D5, was subsequently humanized and developed by Genentech, Inc. as a therapeutic for the treatment of metastatic breast cancer for patients with HER2 gene amplification in their tumor cells. Herceptin was approved by the FDA in 1998 and represents the first targeted therapeutic agent that was developed on the basis of a newly discovered gene with an oncogenic function in human cancer.

 

Ullrich’s second translational project, leading to an FDA-approached cancer therapy, began with the discovery and functional characterization of the receptor tyrosine kinase Flk-1/VEGFR2, as an essential element of the process of tumor angiogenesis. Ullrich’s laboratory demonstrated that blocking this receptor in a mouse brain tumor model, resulted in significantly impaired tumor growth. This approach led to the development of SU11248 (a.k.a. SUTENT/Sunitinib), which was approved by the FDA and the European EMEA, for the treatment of kidney carcinoma and gastro-intestinal stromal tumors, in 2006. SUTENT mediates its therapeutic effects not only through the inhibition of angiogenesis, but also through the interference with multiple kinase targets of cancer cells, while being well proven to be well tolerated by patients. Basic research in Ullrich’s laboratory also led to the characterization of several other medically relevant receptor proteins, including PDGFR, CSF1R, insulin receptor, IGF1R and SCFR/c-kit. Following the prototypical examples of Herceptin and SUTENT, drugs that interfere with the disease-promoting functions of receptor tyrosine kinases are currently being developed in Ullrich´s laboratory and in pharmaceutical companies worldwide. With more than 70,000 citations, he is one of the most frequently cited scientists, in the rapidly progressing era of science of the last 30 years. Prof. Ullrich´s work is an exceptional triumph for biomedical research and has proven its power and benefit to hundreds of thousands of cancer patients.

Medicine

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Emmanuelle Charpentier

Wolf Prize Laureate in Medicine 2020

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Jennifer Doudna

Wolf Prize Laureate in Medicine 2020

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Jeffrey M. Friedman

Wolf Prize Laureate in Medicine 2019

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

James P. Allison

Wolf Prize Laureate in Medicine 2017

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Lewis Cantley

Wolf Prize Laureate in Medicine 2016

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

C. Ronald Kahn

Wolf Prize Laureate in Medicine 2016

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

John Kappler

Wolf Prize Laureate in Medicine 2015

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Philippa Marrack

Wolf Prize Laureate in Medicine 2015

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Jeffrey Ravetch

Wolf Prize Laureate in Medicine 2015

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Victor Ambros

Wolf Prize Laureate in Medicine 2014

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Nahum Sonenberg

Wolf Prize Laureate in Medicine 2014

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Gary Ruvkun

Wolf Prize Laureate in Medicine 2014

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Ronald M. Evans

Wolf Prize Laureate in Medicine 2012

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Shinya Yamanaka

Wolf Prize Laureate in Medicine 2011

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Rudolf Jaenisch

Wolf Prize Laureate in Medicine 2011

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Axel Ullrich

Wolf Prize Laureate in Medicine 2010

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Howard Cedar

Wolf Prize Laureate in Medicine 2008

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Aharon Razin

Wolf Prize Laureate in Medicine 2008

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Anthony R. Hunter

Wolf Prize Laureate in Medicine 2005

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Anthony J. Pawson

Wolf Prize Laureate in Medicine 2005

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Alexander Levitzki

Wolf Prize Laureate in Medicine 2005

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Roger Y. Tsien

Wolf Prize Laureate in Medicine 2004

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Robert A. Weinberg

Wolf Prize Laureate in Medicine 2004

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Ralph L. Brinster

Wolf Prize Laureate in Medicine 2002/3

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Oliver Smithies

Wolf Prize Laureate in Medicine 2002/3

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Mario R. Capecchi

Wolf Prize Laureate in Medicine 2002/3

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Avram Hershko

Wolf Prize Laureate in Medicine 2001

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Alexander Varshavsky

Wolf Prize Laureate in Medicine 2001

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Eric R. Kandel

Wolf Prize Laureate in Medicine 1999

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Ruth Arnon

Wolf Prize Laureate in Medicine 1998

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Michael Sela

Wolf Prize Laureate in Medicine 1998

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Mary F. Lyon

Wolf Prize Laureate in Medicine 1997/8

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Stanley B. Prusiner

Wolf Prize Laureate in Medicine 1996/7

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Yasutomi Nishizuka

Wolf Prize Laureate in Medicine 1995/6

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Michael J. Berridge

Wolf Prize Laureate in Medicine 1995/6

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

M. Judah Folkman

Wolf Prize Laureate in Medicine 1992

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Seymour Benzer

Wolf Prize Laureate in Medicine 1991

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Maclyn McCarty

Wolf Prize Laureate in Medicine 1990

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

John B. Gurdon

Wolf Prize Laureate in Medicine 1989

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Edward B. Lewis

Wolf Prize Laureate in Medicine 1989

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Henri-Géry Hers

Wolf Prize Laureate in Medicine 1988

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Elizabeth F. Neufeld

Wolf Prize Laureate in Medicine 1988

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Pedro Cuatrecasas

Wolf Prize Laureate in Medicine 1987

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Meir Wilchek

Wolf Prize Laureate in Medicine 1987

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Osamu Hayaishi

Wolf Prize Laureate in Medicine 1986

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Donald F. Steiner

Wolf Prize Laureate in Medicine 1984/5

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Solomon H. Snyder

Wolf Prize Laureate in Medicine 1982

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

James W. Black

Wolf Prize Laureate in Medicine 1982

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Jean-Pierre Changeux

Wolf Prize Laureate in Medicine 1982

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Stanley N. Cohen

Wolf Prize Laureate in Medicine 1981

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Barbara McClintock

Wolf Prize Laureate in Medicine 1981

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Leo Sachs

Wolf Prize Laureate in Medicine 1980

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Sir James L. Gowans

Wolf Prize Laureate in Medicine 1980

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

César Milstein

Wolf Prize Laureate in Medicine 1980

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Arvid Carlsson

Wolf Prize Laureate in Medicine 1979

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Roger W. Sperry

Wolf Prize Laureate in Medicine 1979

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Oleh Hornykiewicz

Wolf Prize Laureate in Medicine 1979

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Jon J.van Rood

Wolf Prize Laureate in Medicine 1978

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

Jean Dausset

Wolf Prize Laureate in Medicine 1978

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.

George D.Snell

Wolf Prize Laureate in Medicine 1978

The Wolf Foundation Prize Committee in Medicine has decided to award the first Wolf Prize in Medicine jointly to: George D. Snell , Jean Dausset and Jon J. van Rood

George D. Snell
Jackson Laboratory
Bar Harbor, Maine, USA

“for discovery of H-2 antigens, which codes for major transplantation antigens and the onset of the immune response”.

Dr. George Snell discovered and described in mice the H-2 antigens, the structure which codes for major transplantation antigens carrier genes. These genes are essential in the onset of the immune response and therefore mechanism of defense.

The investigation of histocompatibility antigens in humans, led ProfessorJ. Dausset in Paris and Professor Van Rood in Leiden to the discovery and description of a model similar to that in mice, the HL-A system. This is the major histocompatibility complex in man, and its primordial role in organ transplantation has been extensively established and eva luated. Moreover, the association of HL-A antigens to the mechanisms governing the incidence of a number of diseases is under active research.

These investigations are a major breakthrough in the understanding of modern genetics and have opened new avenues for adequate matching of organ and tissue transplantation and for possible control and prevention of certain diseases.

The name of the late Peter Gorer, the British scientist who was among the founders of this field will be linked forever to the pillars of medical genetics.