Winner of Krill Prize 2019
Krill Prize Laureate 2019 for his research into advanced molecular
biosensors for “multicolor” MRI applications.
Biosensors have become the highlighter felt pens of
modern science; they enable scientists to tag molecules
of interest and have them stand out in striking contrast
to show their location or function in cells and tissues
in colorful relief. However, the available biosensors
used today are based on fluorescent molecules and
thus could not be used in large subjects as humans.
Bar-Shir’s lab aims to develop new biosensors with artificial
“multicolor” features for magnetic resonance imaging
(MRI) applications by combining synthetic chemistry
and molecular biology approaches. Such “multicolor”
biosensors will help the lab study complex and
unrevealed biological events longitudinally and
non-invasively in deep tissues of a live subject. A
successful implementation of the developed
MRI-biosensors will provide Bar-Shir with new capabilities
for early diagnostics of diseases and better assessments
of proposed therapeutics.