
Brian J. Staskawicz
Wolf Prize Laureate in Agriculture 2025

Brian J. Staskawicz
Affiliation at the time of the award:
University of California, Berkeley, USA
Award citation:
“For groundbreaking discoveries of the immune system and disease resistance in plants”.
Prize share:
Brian J. Staskawicz
Jeffery Dangl
Jonathan D. G. Jones
Brian J. Staskawicz (1952, USA) received his Ph.D. in Plant Pathology from the University of California, Berkeley in 1980. He is the Maxine J. Elliot Professor of Plant & Microbial Biology at UC Berkeley, and Director of Sustainable Agriculture at the Innovative Genomics Institute (IGI). Staskawicz is a member of the US National Academy of Sciences and has been elected a Fellow of the American Phytopathological Society and a Fellow of the American Academy of Microbiology. Staskawicz received a B.A. degree from Bates College in Lewiston, Maine, in 1974, a Master of Forest Science degree from Yale University in 1976, and a Ph.D. degree in plant pathology from the University of California, Berkeley, in 1980. After three years at the International Plant Research Institute, in San Carlos, California, he was appointed to the faculty of U.C. Berkeley, where he is now the Maxine J. Elliot Professor and chair of the Department of Plant and Microbial Biology.
Plants are susceptible to various pathogens, including fungi, bacteria, and viruses. This can lead to significant yield losses and threaten the global food supply. For years, it was recognized that individuals within the same plant species exhibit varying disease resistance levels due to dominant alleles at resistance genes. The “gene-for-gene” hypothesis from the 1940s suggested plant disease resistance gene products interact with pathogen avirulence-gene products. However, the nature of, and functions encoded by, plant disease resistance genes remained unknown until the mid-1990s.
Much of our current knowledge of the plant immune system stems from the groundbreaking discoveries made by Jeffery Dangl, Jonathan Jones, and Brian Staskawicz. Staskawicz identified the first bacterial avirulence effector gene, providing crucial molecular evidence supporting the “gene-for-gene” theory. This discovery, alongside parallel work by Jones and Dangl, opened up the field of plant immunity. Staskawicz was also the first to show that bacterial avirulence proteins can have virulence functions inside the plant cell. Jones was the first to clone plant resistance genes that encode eukaryotic cell surface immune receptors, and all three identified multiple intracellular immune receptors. Jones and Dangl independently uncovered mechanisms by which immune receptors are activated through the indirect recognition of pathogen-effector proteins by extracellular and intracellular immune receptors, respectively. The discovery of pathogen effector proteins and plant immune receptors helped illuminate how these receptors are activated upon pathogen detection and helped reveal the downstream signaling pathways.
A landmark 2006 Nature review by Dangl and Jones provided the first detailed, and now textbook, model of the plant immune system. In a 2024 review in Cell, Jones, Dangl, and Staskawicz summarized fifty years of discoveries in plant immunity Their combined contributions significantly shaped our current understanding of the field, leading to targeted strategies to enhance resistance and to control a broad spectrum of plant diseases.
