
Jeffery L. Dangl
Wolf Prize Laureate in Agriculture 2025

Jeffery L. Dangl
Affiliation at the time of the award:
University of North Carolina at Chapel Hill, USA
Award citation:
“For groundbreaking discoveries of the immune system and disease resistance in plants”.
Prize share:
Jeffery Dangl
Jonathan Jones
Brian Staskawicz
Jeffery L. Dangl (1957, USA) is the John N. Couch Distinguished Professor of Biology and an HHMI Investigator at the University of North Carolina at Chapel Hill. A geneticist with a deep interest in the molecular mechanisms of the plant immune system. Dangl graduated from Stanford University with undergraduate degrees in English (Modern Literature) and Biological Sciences in 1981 and earned a doctorate in the Genetics Department of the Stanford University School of Medicine in 1986 for his studies of genetically engineered chimeric monoclonal antibodies in the laboratory of Prof. Leonard A. Herzenberg.
Plants are susceptible to various pathogens, including fungi, bacteria, and viruses. This can lead to significant yield losses and threaten the global food supply. For years, it was recognized that individuals within the same plant species exhibit varying disease resistance levels due to dominant alleles at resistance genes. The “gene-for-gene” hypothesis from the 1940s suggested plant disease resistance gene products interact with pathogen avirulence-gene products. However, the nature of, and functions encoded by, plant disease resistance genes remained unknown until the mid-1990s.
Much of our current knowledge of the plant immune system stems from the groundbreaking discoveries made by Jeffery Dangl, Jonathan Jones, and Brian Staskawicz. Staskawicz identified the first bacterial avirulence effector gene, providing crucial molecular evidence supporting the “gene-for-gene” theory. This discovery, alongside parallel work by Jones and Dangl, opened up the field of plant immunity. Staskawicz was also the first to show that bacterial avirulence proteins can have virulence functions inside the plant cell. Jones was the first to clone plant resistance genes that encode eukaryotic cell surface immune receptors, and all three identified multiple intracellular immune receptors. Jones and Dangl independently uncovered mechanisms by which immune receptors are activated through the indirect recognition of pathogen-effector proteins by extracellular and intracellular immune receptors, respectively. The discovery of pathogen effector proteins and plant immune receptors helped illuminate how these receptors are activated upon pathogen detection and helped reveal the downstream signaling pathways.
A landmark 2006 Nature review by Dangl and Jones provided the first detailed, and now textbook, model of the plant immune system. In a 2024 review in Cell, Jones, Dangl, and Staskawicz summarized fifty years of discoveries in plant immunity Their combined contributions significantly shaped our current understanding of the field, leading to targeted strategies to enhance resistance and to control a broad spectrum of plant diseases.
